Today, biotechnology is more complex and means something more specific. Since the 1970s, new advances in molecular biology have allowed scientists to identify genes and deliberately manipulate DNA molecules in order to discover cures and develop drugs for the treatment of human diseases. The phrase "G to B" is sometimes used when discussing the economics of biotechnology and means "Genes to Drugs." Biotech companies are using the information gathered from the Human Genome Project, as well as other projects that are mapping the genes of non-human organisms and pathogens, to develop drugs and medicines faster than ever thought possible. Here are the most common terms or phrases used when discussing biotechnology, followed by links to other biotech resources as well as the home pages of companies involved in biotech research.

DNA:
Deoxyribonucleic acid, which makes up much of the material found in chromosomes. This is the double stranded molecule composed of nucleotides that make up the genetic material of all living organisms. Each nucleotide consists of a five-carbon sugar, a phosphate group, and one of 4 nitrogen-containing bases: Adenine (A), Guanine (G), Thymine (T) and Cytosine (C). The sequence of these bases is what provides information needed by the cell to assemble amino acids into proteins. Here is a graphic of what a DNA double helix molecule looks lie:

Read more . . .  DNA Learning Center
DNA and Molecular Genetics
Introduction to DNA Structure

Gene: A sequence of DNA that determines the amino acids of a protein. There are approximately 100,000 human genes on the 46 chromosomes that determine virtually every trait in the body. The Human Genome Project (see the description below) began in 1990 to map every gene in an effort to facilitate the discovery of cures and treatments for genetic disorders.

Read more . . .  Human Chromosomes Overview

(Click on any of the 46 human chromosomes and read about it's genes)
Read more . . . 
Genes and Disease

Gene Therapy: In this technique, healthy or modified genes are delivered into an individual's body cells by deactivated viruses or lipid-based compounds in order to correct a genetic defect. Read more by clicking onto the following web sites:

Read more
. . .  American Society of Gene Therapy
Gene Therapy Clinical Trials
Institute for Human Gene Therapy
Introduction to Gene Therapy
National Cancer Institute Q&As About Gene Therapy

Genetic Code
: A group of three DNA bases that specify a specific amino acid. For example, ACG codes for the amino acid threonine, GCG for alanine, etc. A sequence of many genetic codes is called a gene; and the identification of the every genetic code (see Human Genome Project) makes it possible for scientists to develop cure and drugs for the treatment of genetic disorders.

Read more
. . .  Invention of the Genetic Code
Table of Standard Genetic Code


Genetic Engineering
: (see Recombinant DNA Technology)

Human Genome Project: Begun in 1990, the U.S. Human Genome Project is a coordinated effort by the U.S. Department of Energy and the National Institutes of Health, expected to be completed by 2003. Project goals are to:

  • identify all of the more than 100,000 genes in human DNA
  • determine the sequences of the 3 billion chemical base pairs that make up human DNA
  • store this information in databases
  • develop tools for data analysis
  • address the ethical, legal, and social issues (ELSI) that may arise from the project

Read more
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